Chemokine axis CXCL16/CXCR6 in the progression of fibrosis / 中华微生物学和免疫学杂志

ABSTRACT

Fibrosis is the common pathological basis of various lesions. It is mainly manifested as excess collagen deposition and fibrous connective tissue in tissues with destructed structures and impaired function. At present, the pathogenesis of fibrosis is still unclear, and no effective treatment or prevention for fibrosis is available. In recent years, numerous studies have shown that chemokine CXCL16 and its receptor CXCR6 play an important role in the development of fibrosis. This paper summarizes the biological character-istics of CXCL16/CXCR6 axis and its role in fibrosis.