The circadian ryhthm variation of melatonin receptor in peripheral leukoc ytes in patients with acute cerebral infarction / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 21-23, 2001.
Article
in Chinese
| WPRIM
| ID: wpr-735325
ABSTRACT
Objective:
To investigate the circadian ryhthm v ariation of 2-125I-iodomelatonin (125I-Mel) binding sites in the human peripheral leukocytes in patients with acute cerebral infarction.Methods:
Melatonin binding sites in the human peripheral leukocytes were studied using 125 I-Mel as a radioligand (radioligand binding assays).A ll patients [age (70.18±11.70) years] were diagnosed by CT according to the standard [Chin J Nerv, 1996,29(6)379]. We also studied 15 age-match ed healthy old people as the control [age (68.33±7.76) years]. Resul ts The circadian ryhthm variation of 125 I-Mel specific binding in control remained significant (P<0.01) with a higher value at midlight [ (0.16±0.049) fmol/106] than at middark [(0.078±0.035) fmol/106] with one point analysis. There was no significant variation in the patient grou p (P>0.05). The specific binding in the peripheral leukocytes at midlight in the patients with acute cerebral infarction were lower than that of the control .Conclusion:
The expression of Mel receptor decreases in the pa tients wit h acute cerebral infarction and the circadian ryhthm variation of 2-125I -Mel appears abnormal.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Academic Journal of Second Military Medical University
Year:
2001
Type:
Article
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