Mechanism of chitosan inhibiting rabbit aortic smooth muscle cell prolif eration / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 159-160, 2001.
Article
in Chinese
| WPRIM
| ID: wpr-735355
ABSTRACT
Objective:
To study the mechanism of chitosan i n inhibiting the proliferation of rabbit aortic smooth muscle cells(SMCs).Methods:
By means of c-myc probe labelled with random primers and Northern blot hybridization, we examined the effect of chitosan on vascu lar SMC c- myc mRNA expression, which was stimulated by newborn bull serum (NB S,20%).Results:
The oncogene c-myc mRNA expression incerased in cultured vascular SMC 24 h after NBS exposure. These effects were inhibite d by chitosan (20 μg/ml).Conclusion:
Chitosan might inhibit the expression of vascular SMC c-myc mRNA stimulated by NBS, through which the proliferation of vascular SMC are inhibited.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Academic Journal of Second Military Medical University
Year:
2001
Type:
Article
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