Effect of insulin-like growth factor-Ⅰ on osteocalcin secretion of periodontal ligament cells / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 456-458, 2001.
Article
in Chinese
| WPRIM
| ID: wpr-735404
ABSTRACT
Objective:
To investigate the effect of insulin-like growth factor-Ⅰon osteocalcin secretion in periodontal ligament cells.Methods:
Human periodontal ligament cells were cultured by tissue explant in vitro, and the concentration of osteocalcin were determined with radio-immunological method.Results:
Under the condition of L-ascorbic acid and β-glycerophosphate in culture medium, human periodontal ligament cells secreted osteocalcin time-dependently and peaked at the third week; IGF-Ⅰ3.125 ng/ml,6.250 ng/ml, 12.500 ng/ml, 25.000 ng/ml could promote the secretion of osteocalcin dose dependently.Conclusion:
IGF-Ⅰ can increase the secretion of osteocalcin in human periodontal ligament cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Academic Journal of Second Military Medical University
Year:
2001
Type:
Article
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