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Effects of irradiation and W11-a12 on anion-selective channel of mouse peritoneal macrophage / 第三军医大学学报
Article in Zh | WPRIM | ID: wpr-735482
Responsible library: WPRO
ABSTRACT
Objective To study the effects of irradiation and W11-a12,a kind of repair-promoting drug,on anion-selective channel in membranes of mouse peritoneal macrophage. Methods The activity of anion-selective channel was recorded from cell-attached patches with patch clamp techniques. Results The effects of irradiation on anion-selective channel in membranes of peritoneal macrophage included:①decreasing the mean number of activated channels by the presence of zymosan; ②prolonging the mean time from stimulus to the opening of channels; ③depressing the opening of channels by decreasing open-state probability,shortening open-time and prolonging close-time. The effects of irradiation could partly be depressed by W11-a12. Conclusion Irradiation will depress the anion-selective channel of peritoneal macrophage, which may be an important way to depress the function of macrophage.
Full text: 1 Index: WPRIM Language: Zh Journal: Journal of Third Military Medical University Year: 2001 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: Journal of Third Military Medical University Year: 2001 Type: Article