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Prospective Analysis of Factors that Affect Change of Lipoprotein(a) in Hemodialysis Patients During 2 Years / 대한신장학회잡지
Korean Journal of Nephrology ; : 707-712, 2000.
Article in Korean | WPRIM | ID: wpr-73553
ABSTRACT
Lipoprotein(a) [Lp(a)] is an independent risk factor for cardiovascular disease that is a major cause of death in dialysis patients. It has been described to be increased in chronic renal failure patients on conservative treatment or dialysis. It has also been suggested that high concentration of Lp(a) correlates to malnutrition of hemodialysis patients, but this has unproven. The aim of our study was the evaluation of factors that affect changes of Lp(a) concentration through follow up in hemodialysis patients. We assessed the serum concentrations of lipoprotein(a), serum albumin, nPCR, various biochemical parameters and Kt/V as adequacy of dialysis in 25 hemodialysis patients over a 48-months period. The mean serum concentrations of Lp(a) were 40.0+/-21.3mg/dL at basal level, 39.2+/-16.6mg/dL after 48 months, respectively. Significant correlation was found between basal and follow up Lp(a) levels(r=0.76, p=0.0001). Moreover, a significant inverse correlation was observed between changes of serum Lp(a) level and changes of serum albumin level(r=-0.507, p=0.027). However no significant correlation was found between changes of serum Lp(a) level and changes of lipid profiles, nPCR, URR and Kt/V. Our data suggests the possibility of the influence of nutritional status(changes of serum albumin) on changes of serum Lp(a) level in hemodialysis patients. Further prospective studies are warranted to clarify the influence of nutritional status on the Lp(a) in hemodialysis patients.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Serum Albumin / Cardiovascular Diseases / Nutritional Status / Risk Factors / Follow-Up Studies / Cause of Death / Renal Dialysis / Lipoprotein(a) / Malnutrition / Dialysis Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Humans Language: Korean Journal: Korean Journal of Nephrology Year: 2000 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Serum Albumin / Cardiovascular Diseases / Nutritional Status / Risk Factors / Follow-Up Studies / Cause of Death / Renal Dialysis / Lipoprotein(a) / Malnutrition / Dialysis Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Humans Language: Korean Journal: Korean Journal of Nephrology Year: 2000 Type: Article