Nandrolone Decanoate-Induced Transient Ultrafiltration Failure in End Stage Renal Disease Patients Undergoing Dialysis / 대한신장학회잡지
Korean Journal of Nephrology
;
: 687-695, 2000.
Article
in Korean
| WPRIM
| ID: wpr-73555
ABSTRACT
Nandrolone decanoate(ND), one of the anabolic steroids, has been used by athletes to build muscle mass and enhance weight-lifting performance and has also shown to be useful in malnourished ESRD patients. However, ND has several adverse effects including edema. After we experienced a case of severe edema and transient ultrafiltration failure(TUF) requiring more frequent number of dialysis during ND treatment, we prospectively studied the incidence and clinical characteristics of TUF during ND treatment. Among 30 ND-treated patients, 7 patients developed TUF. All TUF+ patients were female and had sigificantly higher number of patients with congestive heart failure, more use of minoxidil and moderate to severe malnutrition than TUF- patients. There were no significant differences in age, duration of dialysis, and number of diabetics between TUF+ and TUF- group. In ND-treated male patients, the number of patients with CHF and moderate to severe malnutrition and with use of minoxidil were significantly lower than TUF+ ones. Body weight and serum albumin concentrations were significantly increased 2-3 months after ND treatment in TUF+ patients. But there were no differences in body weight and serum albumin in TUF-patients. In TUF+ patients, frequency of HD increased from 3 times to 4 to 6 times a week. CAPD patients with TUF+ had more frequently used 4.25% dialysate and number of exchanges were increased. In most TUF+ patients, severe edema and TUF were disappeared about 2 weeks after treatment. Most TUF+ patients returned to previous schedle of dialysis. In conclusion, ND seems to induce TUF in ESRD patients who had risk for volume regulation such as CHF, hypoalbuminemia, or the use of minoxidil.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Steroids
/
Body Weight
/
Serum Albumin
/
Ultrafiltration
/
Incidence
/
Prospective Studies
/
Renal Dialysis
/
Peritoneal Dialysis, Continuous Ambulatory
/
Hypoalbuminemia
/
Malnutrition
Type of study:
Incidence study
/
Observational study
/
Prognostic study
Limits:
Female
/
Humans
/
Male
Language:
Korean
Journal:
Korean Journal of Nephrology
Year:
2000
Type:
Article
Similar
MEDLINE
...
LILACS
LIS