Your browser doesn't support javascript.
loading
Relationship between the Expression of α1-Antitrypsinase in Bronchioalveolar Carcinoma and Clinical Pathology / 华中科技大学学报(医学)(英德文版)
Article in Zh | WPRIM | ID: wpr-735643
Responsible library: WPRO
ABSTRACT
By using immunohistochemistry LSAB method and imaging analysis technique, the expression of α1-antitrypsinase (α1-AT) in 41 cases of bronchioalveolar carcinoma (BAC) was quantitatively detected to explore the relationship between αl-AT expression in BAC tissues and clinical pathology. The results showed that the total positive rate for αl-AT expression was 85.4%. The positive rate for αl-AT expression in alveolar BAC was 100%, with the immunity reactive staining intensity being significantly higher than in papillary BAC, mucinous BAC or sclerosing BAC (P<0.05). The positive rate in papillary BAC was 93.3%, with the intensity higher mucinous BAC or sclerosing BAC (P<0.01); The positive rate in both mucinous BAC and sclerosing BAC was 66.7% (P>0.05); The expression intensity in lymph node metastatic group was obviously lower than that in the group without metastasis (P<0.01); The patients with mucinous BAC were diagnosed at a younger age than those with other histologic types of BAC (P<0.05). It was suggested that BAC cells could also produce αl-AT. Detection of α1-AT could be used as a new method to diagnose BAC and might play a role in assessing BAC metastasis.
Key words
Full text: 1 Index: WPRIM Language: Zh Journal: Journal of Huazhong University of Science and Technology (Medical Sciences) Year: 2000 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: Journal of Huazhong University of Science and Technology (Medical Sciences) Year: 2000 Type: Article