Reproducibility of Gated Myocardial Perfusion SPECT for the Assessment of Myocardial Function : Comparison with Thallium-201 and Technetium-99m-MIBI / 대한핵의학회잡지
Korean Journal of Nuclear Medicine
;
: 381-392, 2000.
Article
in Korean
| WPRIM
| ID: wpr-73600
ABSTRACT
PURPOSE:
We compared the reproducibility of 201Tl and 99mTc-sestamibi (MIBI) gated SPECT measurement of myocardial function using the Germano algorithm. MATERIALS ANDMETHODS:
Gated SPECT acquisition was repeated in the same position in 30 patients who received 201Tl and in 26 who received 99mTc-MIBI. The quantification of end-diastolic volume (EDV), end-systolic volume (ESV), and ejection fraction (EF) on 201Tl and 99mTc-MIBI gated SPECT was processed independently using Cedars quantitative gated SPECT software. The reproducibility of the assessment of myocardial function on 201Tl gated SPECT was compared with that of 99mTc-MIBI gated SPECT.RESULTS:
Correlation between the two measurements for volumes and EF was excellent by the repeated gated SPECT studies of 201Tl (r=0.928 to 0.986; p<0.05) and 99mTc-MIBI (r=0.979 to 0.997; p<0.05). However, Bland Altman analysis revealed the 95% limits of agreement (2 SD) for volumes and EF were tighter by repeated 99mTc-MIBI gated SPECT (EDV 14.1 ml, ESV 9.4 ml and EF 5.5%) than by repeated 201Tl gated SPECT (EDV 24.1 ml, ESV 18.6 ml and EF 10.3%). The root mean square (RMS) values of the coefficient of variation (CV) for volumes and EFs were smaller by repeated 99mTc-MIBI gated SPECT (EDV 2.1 ml, ESV 2.7 ml and EF 2.3%) than by repeated 201Tl gated SPECT (EDV 3.2 ml, ESV 3.5 ml and EF 5.2%).CONCLUSION:
99mTc-MIBI provides more reproducible volumes and EF than 201Tl on repeated acquisition gated SPECT. 99mTc-MIBI gated SPECT is the preferable method for the clinical monitoring of myocardial function.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Perfusion
/
Tomography, Emission-Computed, Single-Photon
/
Technetium Tc 99m Sestamibi
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Nuclear Medicine
Year:
2000
Type:
Article
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