Association between parental exposure to environmental risk factors and the risk of childhood acute lymphoblastic leukemia / 中华流行病学杂志

ABSTRACT

Objective To investigate the association between parental environmental risk factors exposure and the risk for childhood acute lymphoblastic leukemia (ALL).Methods A total of 179 ALL children cases were selected in Tianjin Blood Disease Hospital and 136 healthy children matched by age,gender and living place were selected in 2015 for a case control study.The data were analyzed with univariate and multivariate non conditional logistic regression models.Results The results of multivariate logistic regression analysis indicated that sex,history of abortion,exposure in a smoking environment during pregnancy,catching a cold,taking antipyretic analgesics,maternal exposure to air purifying agent,father's occupational exposure to petroleum products and home decoration during pregnancy were associated with the risk of childhood ALL (P＜0.05) and the results of multivariate logistic regression analysis indicated that sex,history of abortion,catching a cold,father's occupational exposure to petroleum products and home decoration during pregnancy were associated with the risk of childhood ALL (P＜0.05).Conclusion The five factors including sex,history of abortion,catching a cold,father's occupational exposure to petroleum products and home decoration during pregnancy were risk factors for childhood ALL.