HIV genetic subtypes and HIV drug resistance in China: a Meta-analysis / 中华流行病学杂志

ABSTRACT

Objective To assess the relationship between HIV genetic subtypes and HIV resistance in China.Methods The literature retrieval was conducted by using Chinese ScienceTechnology Journal Database (VIP),Wanfang Data,Chinese Journal Full-text Database (CNKI),PubMed and Web of Science to select the papers on the relationship between HIV subtypes and HIV drug resistance in China during 2005-2015.Eligible papers were included according to the inclusion.Meta-analysis was performed by using software Stata 12.0.Results A total of 43 papers were selected and the pooled rate of drug resistance was 15.1％ and the rate of primary drug resistance was 9.5％,the subtypes associated drug resistance were CRF01_AE,CRF07 BC,CRF08_ BC,B/B'and C.The pooled rates of drug resistance of each subtype were 12.8％,7.4％,14.3％,25.7％ and 34.9％ and the rates of primary drug resistance of each subtype were 7.3％,5.7％,11.5％,15.5％ and 23.9％,respectively.Subgroup analysis showed that both treated and area subgroup showed a significant difference among groups (P＜0.05).The rates of primary resistance of each subtype in northern China and southwestern China were higher than that in southern China.Conclusion The distribution of HIV genotypes in China was complex and the prevalence of primary drug resistance of each subtype was high,together with a significant difference among subtypes.It is necessary to strengthen the monitoring of different subtypes of drug resistant strains in China to prevent the recombination and spreading of resistant strains.