Progress in next-generation sequencing research of non-syndromic oral clefts / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 387-390, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-736499
ABSTRACT
Non-syndromic oral clefts (NSOC) are among the most common birth defects.The prevalence of NSOC is 1.13-1.30 per 1 000 live births in China,which is higher than those in other major ethnic groups.The etiology of NSOC is complex and heterogeneous,which involves both genetic and environmental risk factors.Although genome-wide association studies have identified a number of risk loci,these loci can only account for a small proportion of the heritability of NSOC.The next-generation sequencing research provides new ideas for further exploring the genetic risk factors of NSOC.This paper summaries the progress in the next-generation sequencing research of NSOC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
/
Risk factors
Language:
Chinese
Journal:
Chinese Journal of Epidemiology
Year:
2018
Type:
Article
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