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Analysis on 10 year survival of HIV/AIDS patients receiving antiretroviral therapy during 2003-2005 in Henan province / 中华流行病学杂志
Chinese Journal of Epidemiology ; (12): 966-970, 2018.
Article in Chinese | WPRIM | ID: wpr-736612
ABSTRACT
Objective To understand the survival of HIV/AIDS patients after receiving antiretroviral therapy for 10 year in Henan province and related factors.Methods The database of national integrated management system of HIV/AIDS was used to collect the basic information and follow-up information of HIV/AIDS patients who received antiretroviral therapy between 2003 and 2005 in Henan province.Software SPSS 23.0 was used to analyze the patients' survival and related factors based on the life-table method and Cox proportional hazards model.Results Among the 2 448 HIV/AIDS patients who started antiretroviral therapy during 2003-2005,the men accounted for 53.5%,and women accounted for 46.5%.Up to 70.1% of the patients were aged 40-59 years and 95.5% of the patients had blood borne infections.The patients were observed for 10 years after antiviral treatment,and 719 cases died from AIDS related diseases,with a mortality rate of 3.78/100 per year (719/19 010 per year).The cumulative survival rates of patients within 1-year,3 years,5 years and 10 years were 0.94,0.86,0.78,0.69 respectively.Compared with the patients aged <40 years,the HRs of the patients aged 40-,50-,60-and ≥ 70 years were 1.417 (95%CI0.903-2.222),1.834 (95%CI1.174-2.866),2.422 (95%CI1.539-3.810) and 3.424 (95%CI2.053-5.709) respectively.Compared with patients with baseline CD4+T lymphocyte >350 unit/ul,the HRs of the patients with CD4+T lymphocyte <50 unit/μl,50-199 unit/ul and 200-350 unit/ul were 7.105 (95%CI5.449-9.264),4.175 (95% CI3.249-5.366) and 2.214 (95% CI1.691-2.900) respectively.Compared with the women,the HR of the men was 1.480 (95% CI1.273-1.172).Compared with the patients who received second line ART therapy,the HR of patients receiving no second line therapy was 11.923 (95%CI9.410-15.104).Conclusions The cumulative survival rate the HIV/AIDS patients after 10 years of antiretroviral therapy reached 0.69 in Henan.Male,old age,low basic CD4+T lymphocyte count and receiving no second line therapy were the risk factors for long-term survival of AIDS patients.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study / Risk factors Language: Chinese Journal: Chinese Journal of Epidemiology Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study / Risk factors Language: Chinese Journal: Chinese Journal of Epidemiology Year: 2018 Type: Article