Progress of research on toll-like receptors family gene polymorphism and susceptibility to tuberculosis / 中华流行病学杂志

ABSTRACT

Tuberculosis is a chronic infectious disease caused by Mycobacterium (M.)tuberculosis.Innate immunity plays an important role in the response to M.tuberculosis.Toll-like receptors (TLRs) are important pattern recognition receptors in innate immunity.TLRs serve as switches that play decisive roles in identifying pathogens-related components.Previous studies found that TLR1,TLR2,TLR4,TLR9 were essential to promote the development of innate immune responses.The SNPs of rs4833095,rs5743618,rs3923647 of TLR1,rs57473708,rs3804099 of TLR2 and rs352139,rs5743836 of TLR9 were closely related to the susceptibility of tuberculosis in some populations.And there appeared certain relationship between the polymorphisms of TLR3,TLR6,TLR7,TLR8,TLR10 and the susceptibility of tuberculosis.The normal function of TLRs ensures the body's normal immune response to M.tuberculosis.The diversity of TLRs genes allows different individuals to respond differently to the same pathogen.Studies targeting on the relationship between single nucleotide polymorphism in TLRs and susceptibility to tuberculosis can predict the susceptibility to tuberculosis in some populations,as well as discover new drugs targets.