Association between congenital heart disease and medication taken during pregnancy among women of childbearing age / 中华流行病学杂志

ABSTRACT

Objective To analyze the relationship between medication taken during pregnancy and congenital heart disease of the newborns.Methods A large cross-sectional survey was conducted between August and November 2013.A questionnaire survey was conducted among the childbearing aged women,selected through multistage stratified random sampling in Shaanxi from 2010 to 2013.All of the childbearing aged women under study were in pregnancy and with definite pregnancy outcomes.Multivariable Poisson regression was conducted for data analyses.Results A total of 28 680 cases were included in this study.The proportion of medication taken at any time during pregnancy was 16.0％,and the prevalence of congenital heart disease among the newborns was 67.9/10 000.After adjustment for factors as general demographic characteristic,history of heart disease and drug allergy and the situation of disease during pregnancy of these women,results from the multivariable Poisson regression showed that,factors as taking drugs (RR=1.95,95％ CI1.42-2.68),cold medicine (RR=l.68,95％ CI1.07-2.64),antibiotics (RR=1.90,95％ CI1.25-2.90),salicylates (RR=5.01,95％CI1.84-13.64) and antifungal drugs (RR=10.22,95％CI3.25-32.19)during pregnancy were all related to congenital heart disease,and with the history of taking cold medicine (RR =1.90,95 ％ CI1.01-3.61),antibiotics (RR =2.18,95 ％ CI1.17-4.06),salicylates (RR =6.07,95％CI1.45-25.41),antifungal drugs (RR=21.01,95％CI4.17-105.87) and other drugs (RR=2.31,95％CI1.19-4.47) during early pregnancy.These factors were with higher risks for congenital heart disease.Conclusion Women of childbearing age who took cold medicine,antibiotics,salicylic acid drugs,antifungal drugs and other drugs during early pregnancy would increase the risks related to congenital heart diseases.