Identification and biological characteristic of melatonin receptor in human embr yonic nervous system / 第二军医大学学报
Academic Journal of Second Military Medical University
; (12): 12-14, 2001.
Article
in Zh
| WPRIM
| ID: wpr-736790
Responsible library:
WPRO
ABSTRACT
Objective: To verify whether there exists melatoni n(Mel) receptor in human embryonic nervous system. Methods: Spec ific binding of Mel to embryonic brain and spinal cord was measured by radioliga nd binding assay. Results: 125 I-Mel binding s ites in optomeninx was the most, in eptochiasm and sniff ball was next; GTPγS d ose-de pendently inhibited the binding. Conclusion: The results demonst rate the presence of specific binding of Mel in human embryonic brain and spinal cord. GTPγS has some effect on 125 I-Mel specific binding,support ing the theory that Mel receptor is coupled to inhibitory G-proteins.
Full text:
1
Index:
WPRIM
Type of study:
Diagnostic_studies
/
Prognostic_studies
Language:
Zh
Journal:
Academic Journal of Second Military Medical University
Year:
2001
Type:
Article