Inhibitory effect of ginsenoside Rg3 on tumor neoangiogenesis / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 40-42, 2001.
Article
in Chinese
| WPRIM
| ID: wpr-736797
ABSTRACT
Objective:
To study the mechanism of inhibitory ef fect of ginsenoside Rg3 on tumor growth.Methods:
The chick chor ioallantoic membrane(CAM) test and Lewis lung carcinoma model were used to inves tigate the inhibitory effect of Rg3 on tumor angiogenesis.Results:
Rg3(0.1 or 0.5 mmol/L) obviously inhibited angiogenesis in the CAM. Treatmen t with Rg3 in vivo obviously inhibited Lewis lung carcinoma growth with the inhibition ratio from 23% to about 47%. We also observed that the angiogenesis in implanted Lewis lung carcinoma tissue decreased obviously after treated wit h Rg3 (5, 10, 20 mg/kg).Conclusion:
Rg3 can obviously inhibit t he growth of Lewis lung cancer, the inhibitory effect partially due to the effec t of Rg3 inhibiting neovascularization induced by malignant tumor.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Academic Journal of Second Military Medical University
Year:
2001
Type:
Article
Similar
MEDLINE
...
LILACS
LIS