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Effects of cytokines on the expression of CD40 and CD40 ligand in cultured human monocytes/macrophages / 第二军医大学学报
Academic Journal of Second Military Medical University ; (12): 127-129, 2001.
Article in Chinese | WPRIM | ID: wpr-736814
ABSTRACT
Objective: To investigate the effect of c ytokines (IFN-γ,TNF and IL-1) on the expression of CD40 and CD40 ligand (CD4 0L) in monocytes/macrophages. Methods: The mRNA expression of C D40 and CD40L was measured by RT-PCR and the CD40,CD40L expression on the mono cytes/macrophages were detected by flow cytometric analysis. Results: IFN-γ,TNF and IL-1 could not only significantly up-regulate the mRNA levels of CD40 and CD40L in cultured monocytes/macrophages, but also increase t he expression of CD40 and CD40L. Antioxidant VitE could reduce the expression o f CD40 and CD40L induced by IFN-γ,TNF and IL-1. Conclusion: IFN-γ,TNF and IL-1 can stimulate high expression of CD40 and CD40L . Antio xidant VitE can partially inhibit the expression of CD40 and CD40L induced by cy tokines in cultured monocytes/macrophages.
Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Academic Journal of Second Military Medical University Year: 2001 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Academic Journal of Second Military Medical University Year: 2001 Type: Article