A Study of Topical Corticosteroid Effect on the Rat Skin Mast Cell / 대한피부과학회지
Korean Journal of Dermatology
;
: 22-27, 1988.
Article
in Korean
| WPRIM
| ID: wpr-73720
ABSTRACT
The effect of long-term topical application of corticosteroids on rat cutaneous mast cells was examined under the light microscopy. Two potent corticosteroids, 0.05% clobetasol-17-propionate and 0.25% desoxymethasone, produced a remarkable decresse greater than 50% of pretreatment mast cell number by two weeks. Wheress a less potent corticosteroid, 0.1% hydrocotisone-17-valerate, produced a remarkable decrease greater than 50% of pretreatment mast cell number by four weeks. All corticosteroids produced a remarkable decrease greater than 80% of pretreatment mast cell number by six weeks. These results suggest that long-term topical application of corticosteroids may have the deleterious effects on cutsneous mast cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Skin
/
Desoximetasone
/
Adrenal Cortex Hormones
/
Mast Cells
/
Microscopy
Limits:
Animals
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
1988
Type:
Article
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