Correlation between high risk type human papillomavirus E6/E7 mRNA and cervical cancer / 中华流行病学杂志

ABSTRACT

Objective To investigate the correlation between the positive rate of high risk human papillomavirus (HPV) mRNA E6/E7 and cervical cancer,and provide evidence for the prevention and treatment of cervical cancer.Methods A total of 100 cervical cancer cases and 100 healthy controls were selected in our hospital from January 2015 to December 2015.The fluorescence quantitative PCR and pathological examination on HPV E6/E7 mRNA were carried out.The correlation between HPV E6/E7 mRNA and cervical squamous epithelial lesions were analyzed.Results In case group,the positive rate ofHPV E6/E7 mRNA was 76.0％ (76/100).In control group,the positive rate was 13.0％ (13/100).The positive rate in case group was significantly higher than that in control group,and the difference was statistically significant (x2=24.522,P＜0.001).The positive predictive value and negative predictive value of the two groups were compared,and the difference was not significant (P＞0.05).The positive rate of HPV E6/E7 mRNA was significantly higher than high-grade squamous intraepithelial lesion (SIL) rate (26.1％),low-grade SIL rate (17.6％) and atypical squamous cell hyperplasia rate (6.7％),the difference was statistically significant (x2=7.615,P=0.001;x2=9.114,P=0.001;x2=18.241,P＜0.001).Conclusions The detection rate ofHPV E6/E7 mRNA in cervical cancer patients was high.And with the increased severity of cervical squamous epithelial lesions,the positive rate of HPV E6/E7 mRNA increased.