Acceptability of pre-exposure HIV prophylaxis clinical trial among MSM in Shenyang city / 中华流行病学杂志

ABSTRACT

Objective To investigate the acceptability and related factors of an "on-demand"pre-exposure prophylaxis (PrEP) to prevent HIV transmission among MSM in Shenyang.Methods MSM recruited by non-probability sampling method and questionnaire survey conducted by investigators to collect information on social and behavioral characteristics,awareness of PrEP,Truvada and the acceptability of two different PrEP-based trials.Multivariate logistic regression was employed for statistical analysis.Results Among the 292 respondents,34.2％ had heard of PrEP and 58.2％ (170/292) reported were interested in participating a PrEP trial-"on-demand" use or 48.3％ (141/292) interested on "daily" use (x2=5.785,P=0.02).Factors independently associated with those "on-demand" would includehaving more than 2 male sexual partners during the past 6 month (aOR=1.7,95％CI1.1-2.7),concerning on the positive effect of PrEP (vs.side effects) (aOR=6.4,95％CI2.2-18.9),having an HIV-infected sexual partners (aOR=8.1,95％ CI1.0-63.3) and self-reported high risk for HIV (aOR=2.6,95％CI1.2-6.0).The last two factors were only associated with the "on-demand" group.Conclusions "On-demand" PrEP (as opposed to daily) seemed a more feasible prevention strategy on HIV and particularly in those having high risk behavior of HIV.For those who could not follow the daily medication or having HIV risk perception,"On-demand" basis PrEP trial should be recommended for them to follow.