The Effect of Intracameral Triamcinolone Acetonide Injection on the Cornea in Rabbits
Journal of the Korean Ophthalmological Society
;
: 634-640, 2008.
Article
in Korean
| WPRIM
| ID: wpr-73793
ABSTRACT
PURPOSE:
To evaluate the safety and effects of intracameral triamcinolone acetonide injection in rabbit corneas.METHODS:
Triamcinolone acetonide in the amounts of 0.5, 1, and 2 mg was injected into the anterior chamber of rabbit eyes, and intraocular pressure, corneal thickness, and endothelial cell counts were evaluated on days 1, 3, 7, 14, and 28. Twenty-eight days after triamcinolone acetonide injection, the eyes were enucleated and examined after TUNEL staining.RESULTS:
No statistically significant differences were found among control, 0.5, and 1 mg triamcinolone-injected eyes in central corneal thickness, endothelial cell density, pleomorphism, and polymegathism. There was no difference between 2 mg triamcinolone-injected eyes and control eyes for corneal thickness and cell density, but there were statistically significant differences between these two groups for pleomorphism (p<0.05) and polymegathism (p<0.05).CONCLUSIONS:
The results of this study suggested that intracameral injections of 0.5~1 mg of triamcinolone acetonide are beneficial and cause no toxic effects on corneas.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Triamcinolone
/
Triamcinolone Acetonide
/
Cell Count
/
Cornea
/
In Situ Nick-End Labeling
/
Endothelial Cells
/
Eye
/
Intraocular Pressure
/
Anterior Chamber
Limits:
Animals
Language:
Korean
Journal:
Journal of the Korean Ophthalmological Society
Year:
2008
Type:
Article
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