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Prevalence of drug resistance in treatment-naive HIV infected men who have sex with men in Guangzhou, 2008-2015 / 中华流行病学杂志
Chinese Journal of Epidemiology ; (12): 977-982, 2018.
Article in Chinese | WPRIM | ID: wpr-738082
ABSTRACT
Objective To understand the prevalence of drug resistance in treatment-naive HIV infected men who have sex with (MSM) in Guangzhou.Methods HIV-1 RNA were extracted from the serum specimens of the MSM newly confirmed to be HIV-1 positive,living in Guangzhou and receiving no anti-viral therapy from 2008 to 2015.HIV-1 pol gene segments,including full protease and part reverse transcriptase,were amplified by nested reverse transcription polymerase chain reaction (nested-PCR) and sequenced by Sanger.Subsequently,the sequence data were submitted to Stanford University HIV Drug Resistance Database for drug resistance analysis.Results Among 2 283 HIV infected MSM,HIV-1 pol gene segments were obtained from the serum samples of 1 986 HIV infected MSM aged 16-84 (30.18 ± 8.24) years.Among them,the unmarried accounted for 74.17% (1 473/1 986),those of Han ethnic group accounted for 90.64% (1 800/1 986),those with education level of college or above accounted for 49.65% (986/1 986),those with education level of senior high school or secondary school accounted for 27.14% (539/1 986),those with education level of junior high school or below accounted for 20.89% (415/1 986).The distribution of subtypes was predominated by CRF07_BC (38.22%,759/1 986) and CRF01_AE (34.49%,685/1 986).The overall prevalence of drug resistance was 3.32% (66/1 986).The prevalence of resistance to protease inhibitors (PIs),nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs) were 1.36%(27/1 986),0.65% (13/1 986) and 1.61% (32/1 986),respectively.Subtype B had higher resistance to PIs,NRTIs and NNRTIs and subtype CRF55_01B had highest resistance to NNRTIs compared with other subtypes.In subtype B,the resistant rates to D4T,EFV and NVP were highest (all 4.17%,5/120),followed by those to NFV,AZT and RPV (all 3.33%,4/120).In subtype CRF55_01B,the resistant rates to EFV and NVP were highest (all 5.50%,16/291),followed by those to ETR and RPV (all 5.15%,15/291).Conclusions The prevalence of drug resistance in treatment-naive HIV infected MSM in Guangzhou remained at low level and current antiretroviral drugs are generally effective.However,subtype B and CRF55_01B have higher drug resistance.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Prevalence study Language: Chinese Journal: Chinese Journal of Epidemiology Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Prevalence study Language: Chinese Journal: Chinese Journal of Epidemiology Year: 2018 Type: Article