Source tracing of the Yersinia pestis strains isolated from Heqing county, Yunnan province in 2017 / 中华流行病学杂志

ABSTRACT

Objective To understand the genotype of the Yersinia (Y.) pestis strains isolated from Heqing county,Yunnan province in 2017 and provide evidence for the prevention and control of plague in this area.Methods Ten Y.pestis strains isolated from Heqing were typed by the detections of different region (DFR) and clustered regularly interspaced short palindromic repeats (CRISPRs) as well as multiple-locus variable-number tandem repeat analysis (MLVA).And the results were compared with those of the 93 Y.pestis strains from the adjacent plague foci of Heqing obtained from the established database for clustering analysis.Results The results showed that Heqing strains had the same type of DFR (Genomovar 05) and CRISPRs (Cluster Ca7,Type 22) with isolates from the plague focus in Lijiang.Heqing strains and Lijiang strains were in the same cluster in MST and only VNTR loci N2117 and M23 of Heqing strains were different from that of Lijiang strains.Conclusion The Y.pestis strains isolated from Heqing in 2017 were highly homogenous with the strains isolated from wild rodents in plague focus in Lijiang,and Heqing plague might be the result of further southward spread of Lijiang plague.