Analysis on the spatial-temporal characteristics of hand-foot-mouth disease in Shaanxi province, 2009-2013 / 中华流行病学杂志

ABSTRACT

Objective To study the spatial-temporal dynamical features of hand-foot-mouth disease (HFMD) in Shaanxi Province,so as to provide evidence for the development of relative prevention and control programs on HFMD.Methods Surveillance data of HFMD was collected from the China Information System for Diseases Control and Prevention from 2009 to 2013.Related data on population and gross domestic product (GDP) was obtained from Shaanxi Statistical Yearbook.Statistical tools as R3.4.1,ArcGIS 10.2 and SaTScan 9.2 software were used to describe the spatialtemporal distribution of the disease.Power-law method on spatial-temporal-multicomponent model was used to analyze the spatial-temporal evolution of the HFMD epidemics in Shaanxi Province.Results A total of 229 904 cases of HFMD were reported in Shaanxi Province from 2009 to 2013,with an average annual incidence as 122.50 per 100 000.Obvious seasonal characteristics were noticed,with 71.71％ of the total cases identified between April and July.Counties with high incidence were mainly distributed in the mid-and east parts of Guanzhong area.Through temporal and spatial scan statistics,we identified that Class Ⅰ clustering area was fixed to the central and southeast regions of Shaanxi province which were around Xi'an City between 2009 and 2013,with the relative risk (RR)as 2.24,ranging from 2.18 to 3.08.Results from Power-law analysis showed that the continuous follow-up impact from the previous HFMD epidemics appeared strong in Tongguan,Pucheng districts of Weinan City and Weiyang district of Xi'an,with autoregressive components as 1.14,0.97 and 0.89,respectively.The risk of HFMD seemed high in Huayin city,Changan and Yanta districts and with the endemic components as 5.08,4.12 and 4.08,respectively.Impact of the epidemics on nearby districts was largely seen in Lianhu district of Xi'an,Wugong district of Xianyang and Gaoling district of Xi'an with epidemic components as 2.12,2.08 and 1.77,respectively.The etiological constituents of HFMD were mainly Enterovirus 71 between 2009 and 2012,while HFMD was mainly caused by other entero-viruses,in 2013.Conclusion Significant spatial-temporal heterogeneity of HFMD was seen in Shaanxi province,which called for specific strategies to be developed in the highly endemic areas.