Prevalence and associated risk factors on preterm birth, low birth weight, and small for gestational age among HIV-infected pregnant women in Hunan province, 2011-2017 / 中华流行病学杂志

ABSTRACT

Objective To describe the prevalence of preterm birth (PB),low birth weight (LBW),and small for gestational age (SGA) among HIV-infected pregnant women and to identify associated risk factors in Hunan province.Methods This study appeared a retrospective one on HIV-infected pregnant women retrieved from Information System of Prevention of Mother-to-child Transmission of HIV management in Hunan province,between January 2011 and December 2017.Information regarding demographic characteristics,pregnancy,antiretroviral therapy (ART),husbands/partners' relevant situation and pregnancy outcomes,among these HIV-infected pregnant women were collected and analyzed.The incidence rates on PB,LBW and SGA were calculated.Multivariate logistic regression was used to analyze the associated risk factors.Results A total of 780 HIV-infected pregnant women were enrolled.The prevalence rates on PB,LBW and SGA in HIV-infected pregnant women appeared as 7.9％ (62/780),9.9％ (77/780) and 21.3％ (166/780),respectively.Results from the multivariate logistic regression analysis showed that factors as pregnancy related diseases as moderate/severe anemia,hypertensive,initial time of ART ＜14 gestational weeks (compared to those women without ART during pregnancy) and husbands/partners' age ＞35 years old (compared to husbands/partners' age 26-30 years old) etc.,were associated with an increased risk of PB with adjusted OR as 4.59 (95％CI1.51-13.95),4.90 (95％CI1.56-15.46),2.40 (95％CI1.26-4.56) and 2.29 (95％CI1.21-4.36).For LBW,pregnancy moderate/severe anemia,pregnancy HBV infection and initial time of ART ＜ 14 gestational weeks were associated with an increased risk of LBW,with adjusted OR as 3.28 (95％CI1.13-9.54),4.37 (95％CI1.42-13.44) and 2.68 (95％CI1.51-4.76),respectively.For SGA,pregnancy HBV infection and initial time of ART ＜ 14 gestational weeks were risk factors for SGA,with adjusted OR as 4.41 (95％CI1.43-13.63) and 2.67 (95％CI1.51-4.73),respectively.Conclusion Preterm birth,LBW and SGA were common adverse pregnancy outcomes for HIV-infected pregnant women and were associated with factors as pregnancy complications,ART and husbands/partners' age.