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Primary Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue of the Lacrimal Sac Mimicking Dacryocystitis
Journal of the Korean Ophthalmological Society ; : 779-784, 2018.
Article in Korean | WPRIM | ID: wpr-738567
ABSTRACT

PURPOSE:

We report a case of a young female patient who was diagnosed with a marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma) of the lacrimal sac which mimicked dacrocystitis. CASE

SUMMARY:

A 23-year-old female suffered from epiphora for 3 years in the right eye. She had swelling and a painful lesion at the lacrimal sac 4 months prior and was referred to our hospital due to nasolacrimal duct obstruction and dacryocystitis. Lacrimal irrigation was performed with no passing and regurgitation with mucoid discharge. We performed orbital computed tomography and magnetic resonance imaging which showed a suspected tumor of the lacrimal sac in the right eye. We then performed excision and biopsy of the tumor through the skin approach. The patient was diagnosed with a MALT lymphoma with no systemic involvement. After six cycles of chemotherapy involving rituximab with cyclophosphamide, vincristine, and prednisone, the lesion of the mass and the painful symptoms decreased, which was regarded as a complete response. However, epiphora and eye discharge persisted, showing a nasolacrimal duct obstruction, so we performed endoscopic dacryocystorhinostomy with a lacrimal sac biopsy. The histological examination showed chronic inflammation, but not lymphoma. There was no recurrence of lymphoma at one year postoperatively.

CONCLUSIONS:

If there is an epiphora and palpable lesion in the lacrimal sac area, MALT lymphoma mimicking dacyocystitis may be suspected. After the lymphoma is first diagnosed by excision and biopsy, systemic chemotherapy with dacryocystorhinostomy could be an effective treatment.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Orbit / Recurrence / Skin / Vincristine / Biopsy / Prednisone / Dacryocystorhinostomy / Magnetic Resonance Imaging / Lymphoma, B-Cell, Marginal Zone / Cyclophosphamide Limits: Female / Humans Language: Korean Journal: Journal of the Korean Ophthalmological Society Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Orbit / Recurrence / Skin / Vincristine / Biopsy / Prednisone / Dacryocystorhinostomy / Magnetic Resonance Imaging / Lymphoma, B-Cell, Marginal Zone / Cyclophosphamide Limits: Female / Humans Language: Korean Journal: Journal of the Korean Ophthalmological Society Year: 2018 Type: Article