Effect of Non-vitamin K Antagonist Oral Anticoagulants in Atrial Fibrillation Patients with Newly Diagnosed Cancer
Korean Circulation Journal
;
: 406-417, 2018.
Article
in English
| WPRIM
| ID: wpr-738710
ABSTRACT
BACKGROUND AND OBJECTIVES:
There are limited data on the use of non-vitamin K antagonist oral anticoagulants (NOACs) in atrial fibrillation (AF) patients with cancer. We aimed to assess the efficacy and safety of NOACs in AF patients with cancer in this study.METHODS:
In 2,568 consecutive non-valvular AF patients with newly diagnosed cancer, we analyzed ischemic stroke/systemic embolism (SE), major bleeding, and all-cause death. Based on propensity score matching, 388 matched pairs were included in the NOAC and warfarin groups.RESULTS:
Patient baseline characteristics were comparable between the matched groups. During median follow-up of 1.8 years, the NOAC group had significantly lower incidences of ischemic stroke/SE (p < 0.001), major bleeding (p < 0.001), and all-cause death (p < 0.001) than the warfarin group. Moreover, the incidence of major bleeding was significantly lower in the NOAC group than in the warfarin group with optimal international normalized ratio control (p=0.03). Especially, within 1 year after cancer diagnosis, the incidences of all clinical events were significantly lower in the NOAC group than in the warfarin group.CONCLUSIONS:
In AF patients with newly diagnosed cancer, NOACs showed lower incidences of ischemic stroke/SE, major bleeding, and all-cause death than warfarin, especially within 1 year after cancer diagnosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Research Design
/
Atrial Fibrillation
/
Warfarin
/
Incidence
/
Follow-Up Studies
/
International Normalized Ratio
/
Stroke
/
Diagnosis
/
Embolism
/
Propensity Score
Type of study:
Diagnostic study
/
Incidence study
/
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Korean Circulation Journal
Year:
2018
Type:
Article
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