Preoperative High Neutrophil-Lymphocyte Ratio May Be Associated with Lateral Lymph Node Metastasis in Patients with Papillary Thyroid Cancers
International Journal of Thyroidology
;
: 41-48, 2018.
Article
in English
| WPRIM
| ID: wpr-738928
ABSTRACT
BACKGROUND AND OBJECTIVES:
The present study investigated the association between preoperative neutrophil-to-lymphocyte ratio (NLR) and poor prognostic outcomes in conventional papillary thyroid carcinomas (cPTCs). MATERIALS ANDMETHODS:
Two hundred and five patients who underwent total thyroidectomy for cPTCs larger than 10 mm were evaluated retrospectively. Patients were classified into the low NLR (n=103) and high NLR (n=102) groups by the median NLR value (1.78) and logistic regression analysis was used to evaluate whether the NLR predicted aggressive PTC features. Patients were also classified into the disease-free (n=183) and persistence/recurrence (n=22) groups and Cox regression analysis was used to investigate factors affecting persistence/recurrence by Cox regression analysis.RESULTS:
The high NLR group had a higher presence of lateral lymph node metastasis (p=0.004) and higher radioactive iodine doses (p=0.006) than the low NLR group. High NLR was an independent predictor of lateral lymph node metastasis (LNM) (OR, 2.786; p=0.005) but was not significantly associated with persistence/recurrence.CONCLUSION:
Preoperative high NLR was an independent predictor of lateral LNM in cPTCs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Thyroid Gland
/
Thyroidectomy
/
Thyroid Neoplasms
/
Lymphocytes
/
Logistic Models
/
Retrospective Studies
/
Iodine
/
Lymph Nodes
/
Neoplasm Metastasis
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
International Journal of Thyroidology
Year:
2018
Type:
Article
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