A Case of Aggravation of Thyroid Goiter after Treatment with PD-1 Inhibitor for Breast Cancer in Patients with Underlying Hashimoto's Thyroiditis
International Journal of Thyroidology
;
: 172-175, 2018.
Article
in Korean
| WPRIM
| ID: wpr-738940
ABSTRACT
Anti-programmed cell death-1 (PD-1) humanized monoclonal antibody inhibits PD-1 activity by binding to the PD-1 receptor on T-cells and blocking PD-1 ligands and induces immune tolerance of cancer cells. It has been widely used for various kinds of cancer treatment. However, many immune-related adverse events (irAEs) have been reported because it modulates our immune system. In this case study, we reported a case of 42-year-old woman with Hashimoto's thyroiditis who showed rapid aggravation of thyroid goiter and acute hyperventilation syndrome after treatment with PD-1 inhibitor as a neoadjuvant chemotherapy for breast cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Thyroid Gland
/
Thyroiditis
/
Breast
/
Breast Neoplasms
/
T-Lymphocytes
/
Drug Therapy
/
Programmed Cell Death 1 Receptor
/
Goiter
/
Hyperventilation
/
Immune System
Limits:
Adult
/
Female
/
Humans
Language:
Korean
Journal:
International Journal of Thyroidology
Year:
2018
Type:
Article
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