Helicobacter pylori Eradication in Patients with an Iatrogenic Ulcer after Endoscopic Resection and Peptic Ulcer
The Korean Journal of Helicobacter and Upper Gastrointestinal Research
;
: 30-37, 2018.
Article
in English
| WPRIM
| ID: wpr-738954
ABSTRACT
BACKGROUND/AIMS:
We aimed to compare the outcomes and timing of Helicobacter pylori eradication in patients with iatrogenic and peptic ulcers. MATERIALS ANDMETHODS:
This was a retrospective study of 183 patients treated between 2012 and 2015 with 7-day standard triple therapy after endoscopic resection (ER). The patients were enrolled as the iatrogenic ulcer group and assigned to an early treatment group (n=139, H. pylori eradication initiated 2 days after ER) and a late treatment group (n=44, 8 weeks after ER). During the same period, 152 patients with peptic ulcer were assigned to the peptic ulcer group.RESULTS:
Successful H. pylori eradication was achieved in 141 patients (77.0%) in the iatrogenic ulcer group and 114 (75.0%) in the peptic ulcer group (P=0.661). Among the ER patients, the eradication rate was 79.9% (n=111) in the early treatment group and 68.2% (n=30) in the late treatment group (P=0.109). The adverse event rate was significantly higher in the peptic ulcer group than in the iatrogenic ulcer group (13.8% vs. 4.9%, P=0.005). Compliance and adverse events did not significantly differ between the early and late treatment groups.CONCLUSIONS:
In iatrogenic ulcer, H. pylori eradication can be performed with a relatively lower adverse event rate, regardless of treatment timing, than that in peptic ulcer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peptic Ulcer
/
Ulcer
/
Retrospective Studies
/
Helicobacter pylori
/
Helicobacter
/
Compliance
Type of study:
Observational study
Limits:
Humans
Language:
English
Journal:
The Korean Journal of Helicobacter and Upper Gastrointestinal Research
Year:
2018
Type:
Article
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