Optimal First-line Eradication Regimens for Helicobacter pylori Infection in Patients with Clarithromycin Resistance: A Pilot Study
The Korean Journal of Helicobacter and Upper Gastrointestinal Research
;
: 242-246, 2018.
Article
in Korean
| WPRIM
| ID: wpr-738982
ABSTRACT
BACKGROUND/AIMS:
Helicobacter pylori eradication rates using first-line treatment have decreased due to clarithromycin resistance. The aim of this study was to investigate optimal eradication regimens for patients with clarithromycin resistance in Korea. MATERIALS ANDMETHODS:
A total of 72 patients with confirmed clarithromycin resistance were enrolled from August 2015 to July 2017. Patients were randomized to a 7-day bismuth quadruple therapy (BQT) regimen or a 7-day metronidazole triple therapy (MTT) regimen. Eradication was confirmed using the 13C-urea breath test.RESULTS:
There were no differences in baseline characteristics between the groups. Intention-to-treat eradication rates were 77.8% for the BQT group and 66.7% for the MTT group (P=0.293). Per protocol eradication rates were 87.5% for the BQT group and 77.4% for the MTT group (P=0.292). Adverse events were more frequent in the BQT group.CONCLUSIONS:
Eradication rates using MTT were comparable to those using BQT, and adverse events were less frequent in the MTT group. Thus, MTT may be considered as a first-line regimen for patients with clarithromycin resistance. Since this was a pilot study, a study with a large group is required.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bismuth
/
Breath Tests
/
Pilot Projects
/
Helicobacter pylori
/
Helicobacter
/
Clarithromycin
/
Korea
/
Metronidazole
Type of study:
Controlled clinical trial
/
Practice guideline
Limits:
Humans
Country/Region as subject:
Asia
Language:
Korean
Journal:
The Korean Journal of Helicobacter and Upper Gastrointestinal Research
Year:
2018
Type:
Article
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