A Case of Infantile Nephrotic Syndrome associated with Neuroblastoma
Childhood Kidney Diseases
;
: 91-96, 2018.
Article
in English
| WPRIM
| ID: wpr-739191
ABSTRACT
Nephrotic syndrome in the first year of life, characterized by renal dysfunction and proteinuria, is associated with a heterogeneous group of disorders. These disorders are often related to genetic mutations, but the syndrome can also be caused by a variety of other diseases. We report an infant with nephrotic syndrome associated with a neuroblastoma. A 6-month-old girl was admitted with a 10% weight loss over 10 days and nephrotic-range proteinuria. She was ill-looking, and her blood pressure was higher than normal for her age. Her cystatin-C glomerular filtration rate was decreased, and levels of plasma renin, aldosterone, and catecholamines were elevated. Renal ultrasonography and abdominal computed tomography showed a retroperitoneal prevertebral mass encasing both renal arteries and the left renal vein. The mass was partially resected laparoscopically, and the pathologic diagnosis was neuroblastoma. Findings on a simultaneous renal biopsy were unremarkable. The patient was treated with chemotherapy and several anti-hypertensive drugs, including an alpha blocker. Two months later, the mass had decreased in size and the proteinuria and hypertension were gradually improving. In an infant with abnormal renin-angiotensin system activation, severe hypertension, and nephrotic-range proteinuria, neuroblastoma can be considered in the differential diagnosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Proteinuria
/
Renal Artery
/
Renal Veins
/
Renin-Angiotensin System
/
Biopsy
/
Blood Pressure
/
Weight Loss
/
Catecholamines
/
Ultrasonography
Type of study:
Diagnostic study
Limits:
Female
/
Humans
/
Infant
Language:
English
Journal:
Childhood Kidney Diseases
Year:
2018
Type:
Article
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