The Role of Vitamin D in the Pathogenesis of Adolescent Idiopathic Scoliosis
Asian Spine Journal
;
: 1127-1145, 2018.
Article
in English
| WPRIM
| ID: wpr-739287
ABSTRACT
Several theories have been proposed to explain the etiology of adolescent idiopathic scoliosis (AIS) until present. However, limited data are available regarding the impact of vitamin D insufficiency or deficiency on scoliosis. Previous studies have shown that vitamin D deficiency and insufficiency are prevalent in adolescents, including AIS patients. A series of studies conducted in Hong Kong have shown that as many as 30% of these patients have osteopenia. The 25-hydroxyvitamin D3 level has been found to positively correlate with bone mineral density (BMD) in healthy adolescents and negatively with Cobb angle in AIS patients; therefore, vitamin D deficiency is believed to play a role in AIS pathogenesis. This study attempts to review the relevant literature on AIS etiology to examine the association of vitamin D and various current theories. Our review suggested that vitamin D deficiency is associated with several current etiological theories of AIS. We postulate that vitamin D deficiency and/or insufficiency affects AIS development by its effect on the regulation of fibrosis, postural control, and BMD. Subclinical deficiency of vitamin K2, a fat-soluble vitamin, is also prevalent in adolescents; therefore, it is possible that the high prevalence of vitamin D deficiency is related to decreased fat intake. Further studies are required to elucidate the possible role of vitamin D in the pathogenesis and clinical management of AIS.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Scoliosis
/
Vitamin D
/
Vitamin D Deficiency
/
Vitamin K
/
Vitamins
/
Bone Diseases, Metabolic
/
Fibrosis
/
Calcifediol
/
Bone Density
/
Prevalence
Type of study:
Etiology study
/
Prevalence study
Limits:
Adolescent
/
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Asian Spine Journal
Year:
2018
Type:
Article
Similar
MEDLINE
...
LILACS
LIS