Evaluation of a polyurethane foam dressing impregnated with 3% povidone-iodine (Betafoam) in a rat wound model
Annals of Surgical Treatment and Research
;
: 1-7, 2018.
Article
in English
| WPRIM
| ID: wpr-739554
ABSTRACT
PURPOSE:
The purpose of this study was to evaluate the efficacy of Betafoam in terms of wound healing and safety.METHODS:
Fifty-four male adult Sprague-Dawley rats (weight, 200–250 g) were used in the study. Full-thickness skin defects were created on the back of each rats. The rats were assigned to 6 groups according to the type of wound dressing used (n = 9 for each group) Betafoam, Allevyn-Ag, Mepilex-Ag, Medifoam silver, Polymem-Ag, and gauze. The wound size, histological findings, and amount of DNA on the changed dressings for each group were analyzed and compared.RESULTS:
All groups showed an effective decrease in wound size. However, the differences between Betafoam and the other dressings were statistically significant on day 14 (P < 0.05). The number of newly generated blood vessels in the Betafoam group was significantly higher than in the gauze, Allevyn-Ag, and Medifoam silver groups (P < 0.001). In the Betafoam group, the proportion of collagen deposition was highest and showed a significantly superior arrangement of collagen fibers compared with the gauze, Allevyn-Ag, Mepilex-Ag, and Medifoam silver groups. The total content of the remaining DNA counts of the exchanged dressings were significantly lower in the Betafoam group than the others.CONCLUSION:
Betafoam is effective in wound healing and provides the best performance amongst the various types of dressing materials in terms of re-epithelialization, angiogenesis, collagen deposition, and tissue invasion.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polyurethanes
/
Povidone-Iodine
/
Silver
/
Skin
/
Bandages
/
Wound Healing
/
Wounds and Injuries
/
Blood Vessels
/
DNA
/
Collagen
Type of study:
Prognostic study
Limits:
Animals
/
Humans
/
Male
Language:
English
Journal:
Annals of Surgical Treatment and Research
Year:
2018
Type:
Article
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