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Evaluation of a polyurethane foam dressing impregnated with 3% povidone-iodine (Betafoam) in a rat wound model
Annals of Surgical Treatment and Research ; : 1-7, 2018.
Article in English | WPRIM | ID: wpr-739554
ABSTRACT

PURPOSE:

The purpose of this study was to evaluate the efficacy of Betafoam in terms of wound healing and safety.

METHODS:

Fifty-four male adult Sprague-Dawley rats (weight, 200–250 g) were used in the study. Full-thickness skin defects were created on the back of each rats. The rats were assigned to 6 groups according to the type of wound dressing used (n = 9 for each group) Betafoam, Allevyn-Ag, Mepilex-Ag, Medifoam silver, Polymem-Ag, and gauze. The wound size, histological findings, and amount of DNA on the changed dressings for each group were analyzed and compared.

RESULTS:

All groups showed an effective decrease in wound size. However, the differences between Betafoam and the other dressings were statistically significant on day 14 (P < 0.05). The number of newly generated blood vessels in the Betafoam group was significantly higher than in the gauze, Allevyn-Ag, and Medifoam silver groups (P < 0.001). In the Betafoam group, the proportion of collagen deposition was highest and showed a significantly superior arrangement of collagen fibers compared with the gauze, Allevyn-Ag, Mepilex-Ag, and Medifoam silver groups. The total content of the remaining DNA counts of the exchanged dressings were significantly lower in the Betafoam group than the others.

CONCLUSION:

Betafoam is effective in wound healing and provides the best performance amongst the various types of dressing materials in terms of re-epithelialization, angiogenesis, collagen deposition, and tissue invasion.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Polyurethanes / Povidone-Iodine / Silver / Skin / Bandages / Wound Healing / Wounds and Injuries / Blood Vessels / DNA / Collagen Type of study: Prognostic study Limits: Animals / Humans / Male Language: English Journal: Annals of Surgical Treatment and Research Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Polyurethanes / Povidone-Iodine / Silver / Skin / Bandages / Wound Healing / Wounds and Injuries / Blood Vessels / DNA / Collagen Type of study: Prognostic study Limits: Animals / Humans / Male Language: English Journal: Annals of Surgical Treatment and Research Year: 2018 Type: Article