HisCoM-GGI: Software for Hierarchical Structural Component Analysis of Gene-Gene Interactions
Genomics & Informatics
; : e38-2018.
Article
in En
| WPRIM
| ID: wpr-739675
Responsible library:
WPRO
ABSTRACT
Gene-gene interaction (GGI) analysis is known to play an important role in explaining missing heritability. Many previous studies have already proposed software to analyze GGI, but most methods focus on a binary phenotype in a case-control design. In this study, we developed “Hierarchical structural CoMponent analysis of Gene-Gene Interactions” (HisCoM-GGI) software for GGI analysis with a continuous phenotype. The HisCoM-GGI method considers hierarchical structural relationships between genes and single nucleotide polymorphisms (SNPs), enabling both gene-level and SNP-level interaction analysis in a single model. Furthermore, this software accepts various types of genomic data and supports data management and multithreading to improve the efficiency of genome-wide association study data analysis. We expect that HisCoM-GGI software will provide advanced accessibility to researchers in genetic interaction studies and a more effective way to understand biological mechanisms of complex diseases.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Phenotype
/
Case-Control Studies
/
Statistics as Topic
/
Polymorphism, Single Nucleotide
/
Genome-Wide Association Study
/
Methods
Type of study:
Observational_studies
/
Risk_factors_studies
Language:
En
Journal:
Genomics & Informatics
Year:
2018
Type:
Article