Somatic Mutations from Whole Exome Sequencing Analysis of the Patients with Biliary Tract Cancer
Genomics & Informatics
;
: e35-2018.
Article
in English
| WPRIM
| ID: wpr-739678
ABSTRACT
Biliary tract cancer (BTC) is a rare cancer and is associated with a poor prognosis. To understand the genetic characteristics of BTC, we analyzed whole-exome sequencing data and identified somatic mutations in patients with BTC. Tumors and matched blood or normal samples were obtained from seven patients with cholangiocarcinoma who underwent surgical resection. We discovered inactivating mutations of tumor suppressor genes, including APC, TP53, and ARID1A, in three patients. Activating mutations of KRAS and NRAS were also identified. Our analyses identified somatic mutations in Korean patients with BTC
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Biliary Tract
/
Biliary Tract Neoplasms
/
Genes, Tumor Suppressor
/
Cholangiocarcinoma
/
Exome
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Genomics & Informatics
Year:
2018
Type:
Article
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