Antipsychotic Effects of Quetiapine in Naturalistic Long Term Follow Up Study
Psychiatry Investigation
;
: 128-134, 2010.
Article
in English
| WPRIM
| ID: wpr-73971
ABSTRACT
OBJECTIVE:
This study aimed to examine the effectiveness of quetiapine and the effects of dosage relates to its effectiveness on schizophrenia and schizoaffective disorder in a naturalistic setting in Korean people.METHODS:
This study was a 24-week, open-label, non-comparative, naturalistic study of quetiapine in patients diagnosed with schizophrenia and schizoaffective disorder according to DSM-IV. We stratified the patients into mild [(clinical global impression severity (CGI-S) or =4 at baseline). We investigated the response rate, defined as clinical global impression improvement (CGI-I) < or =2, in the severe group and the aggravation rate in the mild group using the last-observation-carried-forward (LOCF) and the Kaplan-Meier method (K-M).RESULTS:
During the 24 weeks, 151 (18.4%) of the participants dropped out of the study. There was a significant decrease in the mean CGI-S score, from 4.5+/-1.1 at baseline to 2.8+/-1.1 at 24 weeks. The response rate of severe group was 54.5% (estimated by LOCF) and 73.3% (K-M estimated) at 24 weeks. All patients who completed the study had taken a mean quetiapine dosage of 507.9+/-245.9 mg daily. The decrease of CGI-S score in high-dose group (the maximum dose was 750 mg/d or above) was statistically significant than that in recommended-dose group (the maximum dose was less than 750 mg/d).CONCLUSION:
This study demonstrated the long-term effectiveness of quetiapine in the treatment of schizophrenia and schizoaffective disorder in a naturalistic setting in Korean people. This study suggests that higher than recommended quetiapine dosages could be more effective in some patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Psychotic Disorders
/
Schizophrenia
/
Antipsychotic Agents
/
Follow-Up Studies
/
Diagnostic and Statistical Manual of Mental Disorders
/
Dibenzothiazepines
/
Quetiapine Fumarate
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Psychiatry Investigation
Year:
2010
Type:
Article
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