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Histological Changes in Biceps Muscle after Tenotomizing the Biceps Long Head in a Rat Model
Clinics in Shoulder and Elbow ; : 87-94, 2018.
Article in English | WPRIM | ID: wpr-739721
ABSTRACT

BACKGROUND:

Popeye deformity is common after rupture of the biceps muscle's long head tendon. Herein, we report on histological changes in biceps brachii muscles following tenotomy of the long head biceps tendon.

METHODS:

Twelve Sprague-Dawley rats (12-week-old) underwent tenotomy of the long head biceps tendon in the right shoulder. At postoperative weeks 4, 7, and 10, the operative shoulders were removed by detaching the biceps brachii muscle from the glenoid scapula and humerus; the opposite shoulders were removed as controls. H&E staining was performed to elucidate histological changes in myocytes. Oil-red O staining was performed to determine fatty infiltration. Myostatin antibody immunohistochemistry staining was performed as myostatin is expressed by skeletal muscle cells during myogenesis.

RESULTS:

H&E staining results revealed no changes in muscle cell nuclei. There were no adipocytes detected. Compared with that of the control biceps, the cross-sectional area of the long head biceps was significantly smaller (p=0.00). Statistical changes in the total extent of the 100 muscle cells were significant (p=0.00). Oil-red O staining revealed no fatty infiltration. Myostatin antibody immunohistochemical staining revealed no significant difference between the two sides.

CONCLUSIONS:

Muscular changes after tenotomy of the long head biceps included a decrease in the size of the individual muscle cells and in relative muscle mass. There were no changes observed in muscle cell nuclei and no fatty infiltration. Moreover, there were no changes detected by myostatin antibody immunohistochemistry assay.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Rupture / Scapula / Shoulder / Congenital Abnormalities / Tendons / Immunohistochemistry / Rats, Sprague-Dawley / Adipocytes / Muscle, Skeletal / Models, Animal Type of study: Prognostic study Limits: Animals Language: English Journal: Clinics in Shoulder and Elbow Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Rupture / Scapula / Shoulder / Congenital Abnormalities / Tendons / Immunohistochemistry / Rats, Sprague-Dawley / Adipocytes / Muscle, Skeletal / Models, Animal Type of study: Prognostic study Limits: Animals Language: English Journal: Clinics in Shoulder and Elbow Year: 2018 Type: Article