Diagnostic Significance of Fibrin Degradation Products and D-Dimer in Patients With Breast Cancer-Related Lymphedema
Annals of Rehabilitation Medicine
;
: 81-86, 2019.
Article
in English
| WPRIM
| ID: wpr-739824
ABSTRACT
OBJECTIVE:
To find out whether levels of fibrin degradation products (FDP) and D-dimer are increased in breast cancer-related lymphedema (BCRL) as in many vascular diseases. FDP and D-dimer have been used in blood tests to help differentiate deep vein thrombosis in the diagnosis of lymphedema. Levels of FDP and D-dimer are often elevated in patients with BCRL.METHODS:
Patients with BCRL (group I), non-lymphedema after breast cancer treatment (group II), and deep venous thrombosis (group III) from January 2012 to December 2016 were enrolled. Levels of FDP and D-dimer were measured in all groups and compared among groups.RESULTS:
Mean values of FDP and D-dimer of group I were 5.614±12.387 and 1.179±2.408 μg/μL, respectively. These were significantly higher than their upper normal limits set in our institution. Levels of FDP or D-dimer were not significantly different between group I and group II. However, values of FDP and D-dimer in group III were significantly higher than those in group I.CONCLUSION:
Values of FDP and D-dimer were much higher in patients with thrombotic disease than those in patients with lymphedema. Thus, FDP and D-dimer can be used to differentiate between DVT and lymphedema. However, elevated levels of FDP or D-dimer cannot indicate the occurrence of lymphedema.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Vascular Diseases
/
Breast
/
Breast Neoplasms
/
Fibrin Fibrinogen Degradation Products
/
Fibrin
/
Venous Thrombosis
/
Diagnosis
/
Hematologic Tests
/
Lymphedema
Type of study:
Diagnostic study
Limits:
Humans
Language:
English
Journal:
Annals of Rehabilitation Medicine
Year:
2019
Type:
Article
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