Randomized, crossover questionnaire survey of acceptabilities of controlled-release mesalazine tablets and granules in ulcerative colitis patients
Intestinal Research
;
: 87-93, 2019.
Article
in English
| WPRIM
| ID: wpr-740027
ABSTRACT
BACKGROUND/AIMS:
Oral mesalazine is an important treatment for ulcerative colitis (UC), and non-adherence to mesalazine increases the risk of relapse. Controlled-release (CR) mesalazine has 2 formulations tablets and granules. The relative acceptabilities of these formulations may influence patient adherence; however, they have not been compared to date. This study aimed to evaluate the acceptabilities of the 2 formulations of CR mesalazine in relation to patient adherence using a crossover questionnaire survey.METHODS:
UC patients were randomly assigned to 2 groups in a 11 ratio. Patients in each group took either 4 g of CR mesalazine tablets or granules for 6 to 9 weeks, and then switched to 4 g of the other formulation for a further 6 to 9 weeks. The acceptability and efficacy were evaluated by questionnaires, and adherence was assessed using a visual analog scale. The difference in acceptabilities between the 2 formulations and its impact on adherence were assessed.RESULTS:
A total of 49 patients were prospectively enrolled and 33 patients were included in the analysis. Significantly more patients found the tablets to be less acceptable than the granules (76% vs. 33%, P=0.0005). The granules were preferable to the tablets when the 2 formulations were compared directly (73% vs. 21%, P=0.004), for their portability, size, and numbers of pills. The adherence rate was slightly better among patients taking the granules (94% vs. 91%) during the observation period, but the difference was not significant (P=0.139).CONCLUSIONS:
CR mesalazine granules are more acceptable than tablets, and may therefore be a better option for long-term medication.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Tablets
/
Ulcer
/
Patient Acceptance of Health Care
/
Colitis, Ulcerative
/
Prospective Studies
/
Patient Compliance
/
Mesalamine
/
Drug Compounding
/
Medication Adherence
Type of study:
Controlled clinical trial
/
Observational study
Limits:
Humans
Language:
English
Journal:
Intestinal Research
Year:
2019
Type:
Article
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