Effect of Resveratrol on Cell Differentiation and Mineralization in Cultured Odontoblasts
International Journal of Oral Biology
;
: 133-140, 2018.
Article
in Korean
| WPRIM
| ID: wpr-740076
ABSTRACT
Resveratrol (3,4′,5,-trihydroxystilbene), a phytoalexin present in grapes, exerts a variety of actions to reduce superoxides, prevents diabetes mellitus, and inhibits inflammation. Resveratrol acts as a chemo-preventive agent and induces apoptotic cell death in various cancer cells. However, the role of resveratrol in odontoblastic cell differentiation is unclear. In this study, the effect of resveratrol on regulating odontoblast differentiation was examined in MDPC-23 mouse odontoblastic cells derived from mouse dental papilla cells. Resveratrol significantly accelerated mineralization as compared with the control culture in differentiation of MDPC-23 cells. Resveratrol significantly increased expression of ALP mRNA as compared with the control in differentiation of MDPC-23 cells. Resveratrol significantly accelerated expression of ColImRNA as compared with the control in differentiation of MDPC-23 cells. Resveratrol significantly increased expressions of DSPP and DMP-1 mRNAs as compared with the control in differentiation of MDPC-23 cells. Treatment of resveratrol did not significantly affect cell proliferation in MDPC-23 cells. Results suggest resveratrol facilitates odontoblast differentiation and mineralization in differentiation of MDPC-23 cells, and may have potential properties for development and clinical application of dentin regeneration materials.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Regeneration
/
RNA, Messenger
/
Cell Differentiation
/
Cell Death
/
Superoxides
/
Vitis
/
Dental Papilla
/
Dentin
/
Cell Proliferation
/
Diabetes Mellitus
Limits:
Animals
Language:
Korean
Journal:
International Journal of Oral Biology
Year:
2018
Type:
Article
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