Study on the Changes in Distributions and Expressions of Aquaporin5 (AQP5) in Salivary Glands of Mice After Alcohol Ingestion
International Journal of Oral Biology
;
: 185-191, 2018.
Article
in Korean
| WPRIM
| ID: wpr-740085
ABSTRACT
Alcohol intake is known to affect various organs in the human body, causing reduction of salivation in the oral cavity. Hypo-salivation effect of alcohol is a common feature, but the mechanism in salivary glands is still poorly studied. Therefore, in this study, the changes in salivary secretion and water channel protein (aquaporin5, AQP5) in salivary glands of mice were investigated after ethanol administration. Animals were divided in to 4 groups with the control, 4 g/kg ethanol, 8 g/kg ethanol and 16 g/kg ethanol administration groups. One hour after ethanol administration, saliva was collected from the oral cavity, and the animals were killed and parotid and submandibular glands were extracted to analyze the histopathology, AQP5 immunihistochemistry and AQP5 protein level. According to the results, the salivation rate decreased irrespective of the ethanol dose in mice, and viscosities increased with increase in ethanol dose. However, there were no pathological changes in parotid and submandibular glands due to ethanol administration. Expression of AQP5 in parotid and submandibular glands decreased with increase ethanol administration These results indicate that the reduction of salivary secretion due to acute alcohol intake is closely related to decrease of the water channel protein such as AQP5 in parotid glands and submandibular glands, rather than the damage of salivary glands.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parotid Gland
/
Saliva
/
Salivary Glands
/
Salivation
/
Submandibular Gland
/
Viscosity
/
Water
/
Human Body
/
Ethanol
/
Eating
Limits:
Animals
Language:
Korean
Journal:
International Journal of Oral Biology
Year:
2018
Type:
Article
Similar
MEDLINE
...
LILACS
LIS