Comparative Effects of Curcumin and Tetrahydrocurcumin on Dextran Sulfate Sodium-induced Colitis and Inflammatory Signaling in Mice
Journal of Cancer Prevention
;
: 18-24, 2018.
Article
in English
| WPRIM
| ID: wpr-740093
ABSTRACT
BACKGROUND:
Curcumin, a yellow ingredient of turmeric (Curcuma longa Linn, Zingiberaceae), has long been used in traditional folk medicine in the management of inflammatory disorders. Although curcumin has been reported to inhibit experimentally-induced colitis and carcinogenesis, the underlying molecular mechanisms remain largely unresolved.METHODS:
Murine colitis was induced by dextran sulfate sodium (DSS) which mimics inflammatory bowel disease. Curcumin or tetrahydrocurcumin was given orally (0.1 or 0.25 mmol/kg body weight daily) for 7 days before and together with DSS administration (3% in tap water). Collected colon tissue was used for histologic and biochemical analyses.RESULTS:
Administration of curcumin significantly attenuated the severity of DSS-induced colitis and the activation of NF-κB and STAT3 as well as expression of COX-2 and inducible nitric oxide synthase. In contrast to curcumin, its non-electrophilic analogue, tetrahydrocurcumin has much weaker inhibitory effects.CONCLUSIONS:
Intragastric administration of curcumin inhibited the experimentally induced murine colitis, which was associated with inhibition of pro-inflammatory signaling mediated by NF-κB and STAT3.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Body Weight
/
Inflammatory Bowel Diseases
/
Dextran Sulfate
/
Dextrans
/
Colitis
/
Colon
/
Curcumin
/
Curcuma
/
Nitric Oxide Synthase Type II
/
Carcinogenesis
Limits:
Animals
Language:
English
Journal:
Journal of Cancer Prevention
Year:
2018
Type:
Article
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