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Leucrose, a Sucrose Isomer, Suppresses Hepatic Fat Accumulation by Regulating Hepatic Lipogenesis and Fat Oxidation in High-fat Diet-induced Obese Mice
Journal of Cancer Prevention ; : 99-106, 2018.
Article in English | WPRIM | ID: wpr-740097
ABSTRACT
Obesity is currently one of the most serious public health problems and it can lead to numerous metabolic diseases. Leucrose, d-glucopyranosyl-α-(1-5)-d-fructopyranose, is an isoform of sucrose and it is naturally found in pollen and honey. The aim of this study was to investigate the effect of leucrose on metabolic changes induced by a high-fat diet (HFD) that lead to obesity. C57BL/6 mice were fed a 60% HFD or a HFD with 25% (L25) or 50% (L50) of its total sucrose content replaced with leucrose for 12 weeks. Leucrose supplementation improved fasting blood glucose levels and hepatic triglyceride content. In addition, leucrose supplementation reduced mRNA levels of lipogenesis-related genes, including peroxisome proliferator-activated receptor γ, sterol regulatory element binding protein 1C, and fatty acid synthase in HFD mice. Conversely, mRNA levels of β oxidation-related genes, such as carnitine palmitoyltransferase 1A and acyl CoA oxidase, returned to control levels with leucrose supplementation. Taken together, these results demonstrated the therapeutic potential of leucrose to prevent metabolic abnormalities by mediating regulation of plasma glucose level and hepatic triglyceride accumulation.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pollen / Sucrose / Triglycerides / Blood Glucose / RNA, Messenger / Carnitine O-Palmitoyltransferase / Public Health / Fasting / Negotiating / Peroxisomes Limits: Animals Language: English Journal: Journal of Cancer Prevention Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pollen / Sucrose / Triglycerides / Blood Glucose / RNA, Messenger / Carnitine O-Palmitoyltransferase / Public Health / Fasting / Negotiating / Peroxisomes Limits: Animals Language: English Journal: Journal of Cancer Prevention Year: 2018 Type: Article