The Effect of Microbiota on Colon Carcinogenesis
Journal of Cancer Prevention
;
: 117-125, 2018.
Article
in English
| WPRIM
| ID: wpr-740108
ABSTRACT
Although genetic background is known to contribute to colon carcinogenesis, the exact etiology of the disease remains elusive. The organ’s extensive interaction with microbes necessitated research on the role of microbiota on development of colon cancer. In this review, we summarized the defense mechanism of colon from foreign organism, and germ-free animal models that have been employed to elucidate microbial effect. We also comprehensively discussed the metabolic property of microbiota such as butyrate production, facilitation of heme toxicity, bile acid transformation, and nitrate reduction that has been shown to contribute to the development of the tumor. Finally, up-to-date subjects such as the effect of age and gender on microbiota are briefly discussed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bile
/
Butyrates
/
Bile Acids and Salts
/
Colon
/
Colonic Neoplasms
/
Butyric Acid
/
Models, Animal
/
Carcinogenesis
/
Microbiota
/
Genetic Background
Language:
English
Journal:
Journal of Cancer Prevention
Year:
2018
Type:
Article
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