Diagnostic Significance of pH-Responsive Gd³⁺-Based T₁ MR Contrast Agents
Investigative Magnetic Resonance Imaging
;
: 17-25, 2019.
Article
in English
| WPRIM
| ID: wpr-740165
ABSTRACT
We discuss recent advances in Gd-based T₁-weighted MR contrast agents for the mapping of cellular pH. The pH plays a critical role in various biological processes. During the past two decades, several MR contrast agents of strategic importance for pH-mapping have been developed. Some of these agents shed light on the pH fluctuation in the tumor microenvironment. A pH-responsive self-assembled contrast agent facilitates the visualization of tumor size as small as 3 mm³. Optimization of various parameters is crucial for the development of pH-responsive contrast agents. In due course, the new contrast agents may provide significant insight into pH fluctuations in the human body.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Biological Phenomena
/
Human Body
/
Contrast Media
/
Tumor Microenvironment
/
Hydrogen-Ion Concentration
Type of study:
Diagnostic study
Language:
English
Journal:
Investigative Magnetic Resonance Imaging
Year:
2019
Type:
Article
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