Out-sourcing for Trans-presentation: Assessing T Cell Intrinsic and Extrinsic IL-15 Expression with Il15 Gene Reporter Mice
Immune Network
;
: e13-2018.
Article
in English
| WPRIM
| ID: wpr-740199
ABSTRACT
IL-15 is a cytokine of the common γ-chain family that is critical for natural killer (NK), invariant natural killer T (iNKT), and CD8 memory T cell development and homeostasis. The role of IL-15 in regulating effector T cell subsets, however, remains incompletely understood. IL-15 is mostly expressed by stromal cells, myeloid cells, and dendritic cells (DCs). Whether T cells themselves can express IL-15, and if so, whether such T cell-derived IL-15 could play an autocrine role in T cells are interesting questions that were previously addressed but answered with mixed results. Recently, three independent studies described the generation of IL-15 reporter mice which facilitated the identification of IL-15-producing cells and helped to clarify the role of IL-15 both in vitro and in vivo. Here, we review the findings of these studies and place them in context of recent reports that examined T cell-intrinsic IL-15 expression during CD4 effector T cell differentiation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
In Vitro Techniques
/
Dendritic Cells
/
T-Lymphocytes
/
Cell Differentiation
/
T-Lymphocyte Subsets
/
Stromal Cells
/
Receptors, Cytokine
/
Interleukin-15
/
Myeloid Cells
/
Th17 Cells
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Immune Network
Year:
2018
Type:
Article
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