Control of Innate and Adaptive Lymphocytes by the RAR-Retinoic Acid Axis
Immune Network
;
: e1-2018.
Article
in English
| WPRIM
| ID: wpr-740206
ABSTRACT
Lymphocytes, such as T cells, B cells, and innate lymphoid cells (ILCs), play central roles in regulating immune responses. Retinoic acids (RAs) are vitamin A metabolites, produced and metabolized by certain tissue cells and myeloid cells in a tissue-specific manner. It has been established that RAs induce gut-homing receptors on T cells, B cells, and ILCs. A mounting body of evidence indicates that RAs exert far-reaching effects on functional differentiation and fate of these lymphocytes. For example, RAs promote effector T cell maintenance, generation of induced gut-homing regulatory and effector T cell subsets, antibody production by B cells, and functional maturation of ILCs. Key functions of RAs in regulating major groups of innate and adaptive lymphocytes are highlighted in this article.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Tretinoin
/
Vitamin A
/
B-Lymphocytes
/
Killer Cells, Natural
/
Lymphocytes
/
T-Lymphocytes
/
T-Lymphocyte Subsets
/
Myeloid Cells
/
Antibody Formation
Language:
English
Journal:
Immune Network
Year:
2018
Type:
Article
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