Rosai-Dorfman Disease in the Breast with Increased IgG4 Expressing Plasma Cells: A Case Report
Korean Journal of Pathology
;
: 489-493, 2012.
Article
in English
| WPRIM
| ID: wpr-74038
ABSTRACT
Rosai-Dorfman disease (RDD) can present in any anatomic site, but breast involvement is rarely reported. Recently, a relationship between RDD and IgG4-related sclerosing disease has been suggested. Here we report another case of RDD with overlapping features of IgG4-related sclerosing disease occurring in a right breast of a 62-year-old female. On microscopic examination, the mass demonstrated a characteristic zonal pattern of proliferation of large polygonal histiocytes and lymphoplasma cells with stromal fibrosis. Emperipolesis was observed in histiocytes with abundant cytoplasm, which showed immunoreactivity for S-100 protein and CD68; the diagnosis of RDD was made. Sheets of plasma cells in the fibrotic stroma demonstrated positive reactions for IgG and IgG4. The mean count of IgG4-positive plasma cells was 100.2/high power field, and the ratio of IgG4/IgG was 56.7%. Additional findings of stromal fibrosis and obliteration of preexisting breast lobules suggested overlapping features with IgG4-related sclerosing disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Plasma Cells
/
Fibrosis
/
Breast
/
Immunoglobulin G
/
S100 Proteins
/
Fluconazole
/
Histiocytosis
/
Histiocytosis, Sinus
/
Cytoplasm
Limits:
Female
/
Humans
Language:
English
Journal:
Korean Journal of Pathology
Year:
2012
Type:
Article
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